کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6125908 1221037 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reasons for rarity of Th17 cells in inflammatory sites of human disorders
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Reasons for rarity of Th17 cells in inflammatory sites of human disorders
چکیده انگلیسی
A second reason for the rarity of human Th17 cells in the inflammatory sites is their rapid shifting into the Th1 phenotype, which is mainly related to the activity of IL-12 and TNF-α. We have named these Th17-derived Th1 cells as non-classic because they differ from classic Th1 cells for the expression of molecules specific for Th17 cells, such as RORC, CD161, CCR6, IL4I1, and IL-17 receptor E. This distinction may be important for defining the respective pathogenic role of Th17, non-classic Th1 and classic Th1 cells in many human inflammatory disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 25, Issue 4, 15 November 2013, Pages 299-304
نویسندگان
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