A double-blind controlled field trial of doxycycline and albendazole in combination for the treatment of bancroftian filariasis in India

► Doxycycline + ABZ provided the best efficacy by eliminating the circulating mf. ► There was significant differences between the 3 treatments at 12 months. ► Reduction in mf level by depleting Wolbachia was established by RT PCR. ► Adverse reactions were rare and mild.