Oral administration of attenuated Salmonella typhimurium containing a DNA vaccine against rabbit haemorrhagic disease

► A recombinant attenuated Salmonella typhimurium delivering VP60 of RHDV was generated. ► It successfully transferred target gene to rabbit cells. ► It elicited RHDV specific immune response and protects rabbits against RHDV challenge. ► It represents a novel potential oral vaccine against RHDV.