Development and validation of a hepatitis B virus DNA sequencing assay for assessment of antiviral resistance, viral genotype and surface antigen mutation status

- DNA-sequencing based assay determines HBV genotype, resistance and HBsAg mutations.
- Assay reliably interrogates a single PCR amplicon for 900+ patient samples.
- The assay's limit of detection is approximately 141 IU/mL.
- Current nationwide distributions of HBV genotypes in U.S. patients described.
- Frequencies of clinically relevant mutations in U.S. patient population examined.