کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6135752 1224896 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mouse intestinal innate immune responses altered by enterotoxigenic Escherichia coli (ETEC) infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Mouse intestinal innate immune responses altered by enterotoxigenic Escherichia coli (ETEC) infection
چکیده انگلیسی
Enterotoxigenic Escherichia coli (ETEC) is an important cause of human and porcine morbidity and mortality. The current study was conducted to identify intestinal immunity that is altered in a mouse model of ETEC infection. Innate immune responses and inflammation were analyzed. The activation of signal transduction pathways, including toll like receptor 4 (TLR-4)-nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK), was analyzed using immunoblotting and PCR array analyses. We found that ETEC infection promoted the expression of pro-inflammatory cytokines through the activation of the NF-κB and MAPK pathways. Meanwhile, ETEC infection affected sIgA transportation and Paneth cell function. These data improve our understanding of how ETEC causes disease in animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 16, Issue 11, November 2014, Pages 954-961
نویسندگان
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