کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6135816 1224904 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationMolecular mechanisms of Streptococcus dysgalactiae subsp equisimilis enabling intravascular persistence
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Short communicationMolecular mechanisms of Streptococcus dysgalactiae subsp equisimilis enabling intravascular persistence
چکیده انگلیسی

Streptococcus dysgalactiae subsp. equisimilis (SDSE) can cause recurrent bacteremic infection. We have characterized novel virulence properties of an SDSE isolate of type stG485.0 that caused severe sepsis three times in a patient despite that he had opsonizing antibodies to the isolate. An infected aortic aneurysm was suspected to be the focus for the persisting bacteria. For the first time we show that this SDSE isolate, as well as other invasive SDSE isolates, aggregate human platelets and efficiently internalize into human endothelial cells. These properties may aid SDSE to persist and could explain the tendency of SDSE to cause recurrent bacteremia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 14, Issue 4, April 2012, Pages 329-334
نویسندگان
, , ,