کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6136086 | 1224942 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Migratory responses of leukocytes infected with Toxoplasma gondii
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recently, monocytic cells were suggested to systemically transport Toxoplasma tachyzoites during acute infection in mice. The mechanism underlying this shuttling function may partly be explained by dramatically enhanced host-cell motility upon parasite invasion. Here, we report that infection of human and murine macrophages in vitro resulted in augmented migration across a transwell membrane, linked to host-cell differentiation and to the parasite genotype. The hypermotility phenotype was absent in infected monocytes, NK, B or T-cells. In contrast to previous observations with dendritic cells, adoptive transfer of infected macrophages or lymphocytes did not exacerbate infection in mice compared to inoculation with free parasites.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 13, Issue 1, January 2011, Pages 96-102
Journal: Microbes and Infection - Volume 13, Issue 1, January 2011, Pages 96-102
نویسندگان
Henrik Lambert, Isabel Dellacasa-Lindberg, Antonio Barragan,