Porphyromonas gingivalis entry into gingival epithelial cells modulated by Fusobacterium nucleatum is dependent on lipid rafts

► Fusobacterium nucleatum enhances Porphyromonas gingivalis invasion of gingival epithelial cells. ► P. gingivalis and/or F. nucleatum colocalizes with lipid rafts. ► MβCD significantly inhibits host cell invasion by these pathogens. ► P. gingivalis SerB does not play a major role in this fusobacterial enhancement.