کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6138915 | 1594232 | 2015 | 8 صفحه PDF | دانلود رایگان |
- Virus populations change over time to reach a point of equilibrium.
- Variation in the order or titer of inoculum does not affect the final equilibrium.
- Equilibrium is determined by the host, and by the fitness of the viruses involved.
Virus populations, mixtures of viral strains or species, are a common feature of viral infection, and influence many viral processes including infection, transmission, and the induction of disease. Yet, little is known of the rules that define the composition and structure of these populations. In this study, we used three distinct strains of Citrus tristeza virus (CTV) to examine the effect of inoculum composition, titer, and order, on the virus population. We found that CTV populations stabilized at the same equilibrium irrespective of how that population was introduced into a host. In addition, both field and experimental observations showed that these equilibria were relatively uniform between individual hosts of the same species and under the same conditions. We observed that the structure of the equilibria reached is determined primarily by the host, with the same inoculum reaching different equilibria in different species, and by the fitness of individual virus variants.
Journal: Virology - Volume 485, November 2015, Pages 205-212