کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139229 1594237 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Viral membrane fusion
ترجمه فارسی عنوان
فیوژن غشاء ویروسی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی


- Viral fusion proteins overcome the high energy barrier to lipid bilayer merger.
- Different molecular structures but the same catalytic mechanism.
- Review describes properties of three known fusion-protein structural classes.
- Single-virion fusion experiments elucidate mechanism.

Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the agents that fulfill this catalytic function. Despite a variety of molecular architectures, these proteins facilitate fusion by essentially the same generic mechanism. Stimulated by a signal associated with arrival at the cell to be infected (e.g., receptor or co-receptor binding, proton binding in an endosome), they undergo a series of conformational changes. A hydrophobic segment (a “fusion loop” or “fusion peptide”) engages the target-cell membrane and collapse of the bridging intermediate thus formed draws the two membranes (virus and cell) together. We know of three structural classes for viral fusion proteins. Structures for both pre- and postfusion conformations of illustrate the beginning and end points of a process that can be probed by single-virion measurements of fusion kinetics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 479–480, May 2015, Pages 498-507
نویسندگان
,