کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139244 1594237 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The 3 facets of regulation of herpes simplex virus gene expression: A critical inquiry
ترجمه فارسی عنوان
3 جنبه تنظیم علامت ژن ویروس هرپس سیمپلکس: یک تحقیق انتقادی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
On entry into the body herpes simplex viruses (HSV) replicate in a series of steps that involves derepression of viral DNA activated by VP16, a virion protein, and sequential transcription of viral genes in a cascade fashion. HSV also enters into neurons in which viral DNA maintained as heterochromatin and with few exceptions viral gene expression is silenced. A third face of the interaction of HSV with its host cells takes place at the moment when the silenced viral genome in neurons is abruptly derepressed. The available data do no reveal evidence that HSV encodes different regulatory programs for each facet of its interaction with its host cells. Rather the data point to significant gaps in our knowledge of the mechanisms by which each facet is initiated and the roles of the infected cells at each facet of the interaction of viral gene products with the host cell.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 479–480, May 2015, Pages 562-567
نویسندگان
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