کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139883 1594244 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition
چکیده انگلیسی
Some viruses and most eukaryotic cells have microRNAs that regulate the expression of many genes. Although many viral miRNAs have been identified, only a few have been included in in vivo functional studies. Here we show that a Py-encoded miRNA downregulates the expression of the pro-apoptotic factor Smad2, resulting in the suppression of the apoptosis pathway. To study the Py miRNA in an in vivo context, a miRNA-deficient mutant virus was created on the background of the LID virus strain which establishes a rapid and lethal infection in newborn mice. Apoptosis analysis on kidney tissues indicates that the pro-apoptotic pathway is targeted in the infected host as well. Suppression of apoptosis through targeting of Smad2 by the Py miRNA is expected to synergize with anti-apoptotic effects previously attributed to the polyoma tumor antigens in support of virus replication in the natural host.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 468–470, November 2014, Pages 57-62
نویسندگان
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