کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6140055 1594246 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early dexamethasone treatment exacerbates enterovirus 71 infection in mice
ترجمه فارسی عنوان
درمان اولیه دگزامتازون عفونت انتروویروس 71 را در موش ها افزایش می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی


- Dexamethasone treatment has no beneficial effect on enterovirus 71-infected mice.
- Dexamethasone treatment can increase the mortality of enterovirus 71-infected mice.
- Dexamethasone treatment increases tissue viral loads of enterovirus 71-infected mice.

Enterovirus 71 (EV71) infection can induce encephalitis. Overt immune responses is suspected to cause severe symptoms, so anti-inflammatory agents, corticosteroids have been recommended for treatment. However, one clinical study reported that treatment with glucocorticoids, dexamethasone (Dex) exacerbates disease severity. Here we investigated Dex treatment on EV71 infection using the murine model and found that both long-term (14-day) and short-term (4-day) Dex treatment starting from 1 or 3 days postinfection increased the mortality and disease severity of infected mice. Dex treatment starting from 4 or 8 days postinfection did not affect mouse mortality and disease severity. Early Dex treatment starting from 1 day postinfection caused atrophy and enhanced apoptosis in lymphoid organs to decrease the numbers of lymphocytes (CD4+ T cells, CD8+ T cells, and CD19+ B cells) and to increase viral loads in infected tissues of mice. Our results demonstrate that Dex treatment has no beneficial effect on EV71 infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 464–465, September 2014, Pages 218-227
نویسندگان
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