کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6140454 1594251 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice
چکیده انگلیسی


- RSV infection increases lung cellular respiration and ATP in neonatal C57BL/6 mice.
- Increased lung cellular bioenergetics is a biomarker of RSV infection.
- Lung cellular glutathione remains unchanged in RSV infection.

We have previously reported that lung cellular bioenergetics (cellular respiration and ATP) increased in 4-10 week-old BALB/c mice infected with respiratory syncytial virus (RSV). This study examined the kinetics and changes in cellular bioenergetics in ≤2-week-old C57BL/6 mice following RSV infection. Mice (5-14 days old) were inoculated intranasally with RSV and the lungs were examined on days 1-10 post-infection. Histopathology and electron microscopy revealed preserved pneumocyte architectures and organelles. Increased lung cellular bioenergetics was noted from days 1-10 post-infection. Cellular GSH remained unchanged. These results indicate that the increased lung cellular respiration (measured by mitochondrial O2 consumption) and ATP following RSV infection is independent of either age or genetic background of the host.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 454–455, April 2014, Pages 263-269
نویسندگان
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