کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6140553 | 1594254 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection](/preview/png/6140553.png)
چکیده انگلیسی
The contest between the host factor APOBEC3G (A3G) and the HIV-1 protein Vif presents an attractive target of intervention. The extent to which the A3G-Vif interaction must be suppressed to tilt the balance in favor of A3G remains unknown. We employed stochastic simulations and mathematical modeling of the within-host dynamics and evolution of HIV-1 to estimate the fraction of progeny virions that must incorporate A3G to render productive infection unsustainable. Using three different approaches, we found consistently that a transition from sustained infection to suppression of productive infection occurred when the latter fraction exceeded ~0.8. The transition was triggered by A3G-induced hypermutations that led to premature stop codons compromising viral production and was consistent with driving the basic reproductive number, R0, below unity. The fraction identified may serve as a quantitative guideline for strategies targeting the A3G-Vif axis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 449, 20 January 2014, Pages 224-228
Journal: Virology - Volume 449, 20 January 2014, Pages 224-228
نویسندگان
Pulari U. Thangavelu, Vipul Gupta, Narendra M. Dixit,