کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6140651 1594257 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential potential for envelope glycoprotein-mediated steric shielding of host cell surface proteins among filoviruses
ترجمه فارسی عنوان
پتانسیل دیفرانسیل برای محافظت استریک گلیکوپروتئین در پاکت پروتئین سطوح میزبان در میان فیلوویروسها
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی


- Envelope glycoprotein-mediated steric shielding effects differ among filoviruses.
- The steric shielding efficiency is correlated with differential pathogenic potential.
- Overall properties of the GP molecule are important for efficient shielding.

The viral envelope glycoprotein (GP) is thought to play important roles in the pathogenesis of filovirus infection. It is known that GP expressed on the cell surface forms a steric shield over host proteins such as major histocompatibility complex class I and integrin β1, which may result in the disorder of cell-to-cell contacts and/or inhibition of the immune response. However, it is not clarified whether this phenomenon contributes to the pathogenicity of filoviruses. In this study, we found that the steric shielding efficiency differed among filovirus strains and was correlated with the difference in their relative pathogenicities. While the highly glycosylated mucin-like region of GP was indispensable, the differential shielding efficiency did not necessarily depend on the primary structure of the mucin-like region, suggesting the importance of the overall properties (e.g., flexibility and stability) of the GP molecule for efficient shielding of host proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 446, Issues 1–2, November 2013, Pages 152-161
نویسندگان
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