Influence of HIV-associated degree of immune suppression on molecular heterogeneity of hepatitis B virus among HIV co-infected patients

► Significantly high prevalence of HBV genotype D, subgenotype D2. ► Negative association in frequency of HBV/D2 with CD4 count.► Decreased genetic diversity and increased HBV/D2 viral replication in low CD4 count. ► In higher CD4 count more non-synonymous immune/therapy escape mutation in HBV/D2. ► In contrast, in HBV/A1 a reverse trend in genetic diversity with varying CD4 count.