Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores

► We previously identified HSP90AB1 as a host factor essential for HIV replication. ► HSP90AB1 expression rescued infectivity of HIV with incomplete CA-SP1 cleavage. ► Here we show that HSP90AB1 can also rescue HIV with defective cores. ► HSP90AB1 expression increases with hyperthermia. ► Hyperthermia increased HIV infectivity up to 30-fold and rescued CA-mutant virus.