A critical role of N-myc and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV) 2C-induced apoptosis

► FMDV 2C is one of the most highly-conserved proteins among the serotypes of FMDV. ► We found FMDV 2C interacted with a cellular protein Nmi. ► FMDV 2C induced translocation of Nmi from the cytoplasm to the speckles. ► Knockdown of Nmi inhibited FMDV 2C-induced apoptosis.