Comparing PreXMRV-2 gag sequence diversity in laboratory and wild mice using deep sequencing

► PreXMRV-2 like sequence diversity described for wild caught and inbred mice using high-throughput sequencing. ► PreXMRV-2 likely originated in M. m. domesticus. ► PreXMRV-2 not found among rodents sympatric with M. m. domesticus. ► High-throughput sequencing approaches better at identifying specific viruses than low throughput methods.