کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6189353 1257187 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of margin status on outcomes following accelerated partial breast irradiation using single-lumen balloon-based brachytherapy
ترجمه فارسی عنوان
تأثیر وضعیت حاشیه بر پیامدهای بعد از تابش پدیده شتابزده پستان با استفاده از براکیتراپی مبتنی بر بالون تک لومنی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

PurposeTo examine the impact of margin status on clinical outcomes for patients enrolled in the American Society of Breast Surgeons (ASBrS) MammoSite® Registry Trial.Methods and MaterialsOne thousand four hundred forty-nine cases of early-stage breast cancer underwent breast-conserving therapy with a single-lumen balloon-based applicator used to deliver adjuvant accelerated partial breast irradiation (34 Gy in 10, bid fractions). One thousand two hundred fifty-five cases (87%) had invasive breast cancer (median size = 10 mm) and 194 cases (13%) had ductal carcinoma in situ (DCIS; median size = 8 mm).ResultsPatients were stratified by margin status into negative (n = 1326), close (<2mm; n = 110), and positive (n = 13) margins. One hundred twenty-three cases (8.5%) had close or positive margins. Overall, no statistical difference in the 6-year rate of ipsilateral breast tumor recurrence (IBTR) was noted for close margins compared with that of margin-negative patients (8.7% vs. 4.1%, p = 0.10) or for positive margins compared with that of margin-negative patients (14.3% vs. 4.1%, p = 0.41). In patients with DCIS, there was a statistically significant increase in IBTR with close margins (17.6% vs. 4.2%, p = 0.004) and when close and positive margins were pooled (15.7% vs. 4.2%, p = 0.01 with a nonsignificant reduction in disease-free survival for DCIS patients with close margins (82.4% vs. 90.8%, p = 0.12). The increase in IBTR for close and close/positive patients was secondary to statistically significant increases in elsewhere failures rather than true recurrences/marginal misses.ConclusionNonsignificant increases in the rates of IBTR were noted with close and positive margins for invasive cancer with further data required to validate these findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brachytherapy - Volume 12, Issue 2, March–April 2013, Pages 91-98
نویسندگان
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