کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6190472 | 1257371 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cancer treatment-induced bone loss (CTIBL): Pathogenesis and clinical implications
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
Osteopenia and osteoporosis are often long-term complications of anti-neoplastic treatments, defined as “cancer treatment-induced bone loss” (CTIBL). This pathological condition in oncologic patients results in a higher fracture risk than in the general population, and so has a significant negative impact on their quality of life. Hormone treatment is the main actor in this scenario, but not the only one. In fact, chemotherapies, radiotherapy and tyrosine kinase inhibitors may contribute to deregulate bone remodeling via different mechanisms. Thus, the identification of cancer patients at risk for CTIBL is essential for early diagnosis and appropriate intervention, that includes both lifestyle modifications and pharmacological approaches to prevent bone metabolism failure during anti-tumor treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 41, Issue 9, November 2015, Pages 798-808
Journal: Cancer Treatment Reviews - Volume 41, Issue 9, November 2015, Pages 798-808
نویسندگان
S. D'Oronzo, S. Stucci, M. Tucci, F. Silvestris,