Quantitative 1H and hyperpolarized 3He magnetic resonance imaging: Comparison in chronic obstructive pulmonary disease and healthy never-smokers

The significant and moderately strong relationship between 1H SI and 3He ADC, as well as between 1H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1H SI may be used to monitor emphysema as a complement to CT and noble gas MRI.