کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6270916 | 1614746 | 2016 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endogenous opioids regulate glucocorticoid-dependent stress-coping strategies in mice
ترجمه فارسی عنوان
اپیوئید آندوژنی استراتژی های مقابله با استرس وابسته به گلوکوکورتیکوئید را در موش ها تنظیم می کند
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کلمات کلیدی
MifepristoneGCsCTXNTXDEXSAL - WILLStress - استرس یا فشار روانیOpioids - اپیوئیدGene expression - بیان ژنEnzyme-linked immunosorbent assay - تست الیزاELISA - تست الیزاFear conditioning - تهدید ترسDexamethasone - دگزامتازونMIF - شهرPVN - مالیات بر ارزش افزودهCoping - مقابلهMice - موشHPA - میلی بار یا هکتوپاسکالNaltrexone - نالترکسونparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسhypothalamic–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالGlucocorticoids - گلوکوکورتیکوئیدهاOpioid receptor - گیرنده های اوپیوئیدglucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Coping skills are essential in determining the outcomes of aversive life events. Our research was aimed to elucidate the molecular underpinnings of different coping styles in two inbred mouse strains, C57BL/6J and SWR/J. We compared the influence of a preceding stressor (0.5Â h of restraint) on behavioral and gene expression profiles between these two strains. The C57BL/6J strain exhibited increased conditioned fear and high immobility (passive coping). Oppositely, the SWR/J mice demonstrated low freezing and immobility, low post-restraint anxiety and considerable struggling during the forced swim test (active coping). Gene profiling in the amygdala revealed transcriptional patterns that were related to the differential stress reactivity, such as the activation of glucocorticoid-dependent genes specifically in the C57BL/6J mice. Post-restraint blood sampling for corticosterone levels confirmed the association of hypothalamic-pituitary-adrenal (HPA) activation with a passive coping style. Pharmacological tools were used to modulate the stress-coping strategies. The blockade of opioid receptors (ORs) before the aversive event caused transcriptional and neuroendocrine changes in the SWR/J mice that were characteristic of the passive coping strategy. We found that treatment with a glucocorticoid receptor (GR) agonist (dexamethasone (DEX), 4Â mg/kg) impaired the consolidation of fear memory in the C57BL/6J mice and that this effect was reversed by OR blockade (naltrexone (NTX), 2Â mg/kg). In parallel, a glucocorticoid receptor antagonist (mifepristone (MIF), 20Â mg/kg) reversed the effect of morphine (20Â mg/kg) on conditioned fear in the C57BL/6J mice. Our results suggest that in mice, stress-coping strategies are determined by opioid-dependent mechanisms that modulate activity of the HPA axis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 330, 25 August 2016, Pages 121-137
Journal: Neuroscience - Volume 330, 25 August 2016, Pages 121-137
نویسندگان
Klaudia Szklarczyk, Michal Korostynski, Slawomir Golda, Marcin Piechota, Joanna Ficek, Ryszard Przewlocki,