کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6271400 1614763 2016 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action
ترجمه فارسی عنوان
آیا تعامل میان اسیدهای چرب و تریپتوفان مسئول اثربخشی یک رژیم غذایی کتونی در صرع است؟ فرضیه جدید عمل
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
We observed that intragastric administration of FA increased the brain levels of TRP and the central and peripheral concentrations of kynurenic acid (KYNA), as well as caused significant changes in the brain and plasma concentrations of BCAA and AAA. We found that the administration of FA clearly increased the seizure threshold and induced sedation. Furthermore, we have demonstrated that blocking TRP passage into the brain abolished these effects of FA but had no similar effect on the formation of ketone bodies. Given that FAs are major components of a ketogenic diet, it is suggested that the anticonvulsant effects of a ketogenic diet may be at least partly dependent on changes in TRP metabolism. We also propose a more general hypothesis concerning the intracellular mechanism of the ketogenic diet.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 313, 28 January 2016, Pages 130-148
نویسندگان
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