کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272508 | 1614778 | 2015 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early free access to hypertonic NaCl solution induces a long-term effect on drinking, brain cell activity and gene expression of adult rat offspring
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کلمات کلیدی
diaminobenzidine hydrochlorideNHSCVOsBNSTLPBNABPAVPOVLTNTSMNPODRNc-fosPaVSFO5-HTAT1ADABCeA - CEAorganum vasculosum of the lamina terminalis - ارگانواسکوئوزوم ترمینال لامیناcircumventricular organs - اندامهای دور رحمیoxytocin - اکسیتوسینISO - ایزوphosphate buffer - بافر فسفاتanalyses of variance - تجزیه و تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceLamina terminalis - ترمینال لامیناManipulation - دستکاریpostnatal day - روز پس از زایمانnormal horse serum - سرم طبیعی اسبSerotonin - سروتونینarea postrema - طبقه آخرSubfornical organ - عضو زیربنیکیSON - فرزند پسرArterial blood pressure - فشار خون شریانیPVN - مالیات بر ارزش افزودهPalm - نخلSupraoptic nucleus - هسته Supraopticbed nucleus of the stria terminalis - هسته تخت ترمینال های استریnucleus of the solitary tract - هسته دستگاه انفرادیdorsal raphe nucleus - هسته رافهlateral parabrachial nucleus - هسته پاراباژیال جانبی جانبیparaventricular nucleus - هسته پروژسترویکmedian preoptic nucleus - هسته پیشوپتیک مدیاستvasopressin - وازوپرسینbody weight - وزن بدنAntibody - پادتَن یا آنتیبادی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Early free access to hypertonic NaCl solution induces a long-term effect on drinking, brain cell activity and gene expression of adult rat offspring Early free access to hypertonic NaCl solution induces a long-term effect on drinking, brain cell activity and gene expression of adult rat offspring](/preview/png/6272508.png)
چکیده انگلیسی
Exposure to an altered osmotic environment during a pre/postnatal period can differentially program the fluid intake and excretion pattern profile in a way that persists until adulthood. However, knowledge about the programing effects on the underlying brain neurochemical circuits of thirst and hydroelectrolyte balance, and its relation with behavioral outputs, is limited. We evaluated whether early voluntary intake of hypertonic NaCl solution may program adult offspring fluid balance, plasma vasopressin, neural activity, and brain vasopressin and angiotensinergic receptor type 1a (AT1a)-receptor gene expression. The manipulation (M) period covered dams from 1Â week before conception until offspring turned 1-month-old. The experimental groups were (i) Free access to hypertonic NaCl solution (0.45Â M NaCl), food (0.18% NaCl) and water [M-Na]; and (ii) Free access to food and water only [M-Ctrol]. Male offspring (2-month-old) were subjected to iv infusion (0.15Â ml/min) of hypertonic (1.5Â M NaCl), isotonic (0.15Â M NaCl) or sham infusion during 20Â min. Cumulative water intake (140Â min) and drinking latency to the first lick were recorded from the start of the infusion. Our results indicate that, after systemic sodium overload, the M-Na group had increased water intake, and diminished neuronal activity (Fos-immunoreactivity) in the subfornical organ (SFO) and nucleus of the solitary tract. They also showed reduced relative vasopressin (AVP)-mRNA and AT1a-mRNA expression at the supraoptic nucleus and SFO, respectively. The data indicate that the availability of a rich source of sodium during the pre/postnatal period induces a long-term effect on drinking, neural activity, and brain gene expression implicated in the control of hydroelectrolyte balance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 298, 9 July 2015, Pages 120-136
Journal: Neuroscience - Volume 298, 9 July 2015, Pages 120-136
نویسندگان
A.F. Macchione, C. Beas, F.M. Dadam, X.E. Caeiro, A. Godino, L.F. Ponce, J.L. Amigone, L. Vivas,