کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6276937 | 1295746 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiovascular reactivity and neuronal activation to stress in Schlager genetically hypertensive mice
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کلمات کلیدی
CeAmRPADMHSFOSNSMNPOBSTOVLTCVLMRVLMNTSMEAM - MErostral ventrolateral medulla - آرام آرامvascular organ of the lamina terminalis - ارگان عروقی ترمینال لامیناanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancesympathetic nervous system - سیستم عصبی سمپاتیکHeart rate - ضربان قلبarea postrema - طبقه آخرSubfornical organ - عضو زیربنیکیSON - فرزند پسرmean arterial pressure - فشار متوسط شریانیBlood pressure - فشارخونPVN - مالیات بر ارزش افزودهcaudal ventrolateral medulla - مدولال ventrolateral کادالBrain - مغزmap - نقشهSupraoptic nucleus - هسته Supraopticbed nucleus of the stria terminalis - هسته تخت ترمینال های استریnucleus of the solitary tract - هسته دستگاه انفرادیRaphe nucleus - هسته ریفcentral nucleus of the amygdala - هسته مرکزی آمیگدالMedial nucleus of the amygdala - هسته مرکزی آمیگدالparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسmedian preoptic nucleus - هسته پیشوپتیک مدیاستdorsomedial hypothalamus - هیپوتالاموس dorsomedial
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cardiovascular reactivity and neuronal activation to stress in Schlager genetically hypertensive mice Cardiovascular reactivity and neuronal activation to stress in Schlager genetically hypertensive mice](/preview/png/6276937.png)
چکیده انگلیسی
Schlager inbred hypertensive mice (BPH/2J) have been suggested to have high blood pressure (BP) due to an overactive sympathetic nervous system (SNS). The brain nuclei associated with the hypertension are also those involved in the integration of the cardiovascular responses to stress. Therefore, in the present study, we hypothesize that BPH/2J mice likely have a greater response to stress that is associated with greater neuronal activation in the limbic system, hypothalamus and medulla in regions known to regulate sympathetic activity. Male hypertensive BPH/2J and normotensive BPN/3J mice were implanted with telemetry devices and exposed to dirty cage-switch, an acute model of aversive stress. Stress exposure caused a 60% greater pressor response in BPH/2J compared with BPN/3J mice and an increase in activity, by contrast the level of tachycardia was less in BPH/2J mice. Stress-induced cardiovascular responses were also associated with greater neuronal activation, as detected by c-Fos expression, in BPH/2J compared with BPN/3J mice in the medial nucleus of the amygdala (MeAm), dorsomedial hypothalamus (DMH) (P<0.001) and marginally in the rostral ventrolateral medulla (RVLM; P=0.7). These findings suggest that hypertension in the BPH/2J mice is associated with greater sympathetic vasomotor responses to central pathways mediating the arousal responses to acute aversive stress in particular the amygdala, hypothalamus and rostral ventrolateral medulla.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 2, 13 October 2010, Pages 551-558
Journal: Neuroscience - Volume 170, Issue 2, 13 October 2010, Pages 551-558
نویسندگان
P.J. Davern, K.L. Jackson, T.P. Nguyen-Huu, L. La Greca, G.A. Head,