کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277595 | 1295765 | 2009 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Imaging phenotypes of major depressive disorder: genetic correlates
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کلمات کلیدی
COMTVentromedial PFCMAOAfluorodeoxyglucoseWMHvmPFCBNSTVLPFCFDGOFCPAGVNTR5-HTTCatechol-O-methyltransferaseCNVECTMDDBOLDtph25-HT1A receptor - 5-HT1A گیرندهEndophenotype - آندوفنوتیپ Major depressive disorder - اختلال افسردگی عمدهbipolar disorder - اختلال دو قطبیseasonal affective disorder - اختلال عاطفی فصلیMRI - امآرآی یا تصویرسازی تشدید مغناطیسیGenome-wide association - انجمن گسترده ژنومEpigenetics - اپی ژنتیکtryptophan hydroxylase-2 - تریپتوفان هیدروکسیلاز 2Magnetic resonance imaging - تصویربرداری رزونانس مغناطیسیfMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیPositron emission tomography - توموگرافی گسیل پوزیترونvariable number tandem repeat - تکرار تعداد متغیرsgACC - تیم ملی5-HT transporter - حمل کننده 5-HTperiaqueductal gray - خاکستری پرآبیAntidepressant medication - داروهای ضد افسردگیElectroconvulsive therapy - درمان با ضربه الکتریکی تشنجآور، الکتروشوک درمانیCognitive-behavior therapy - درمان شناختی-رفتاریCBT - رفتار درمانی شناختی serotonin transporter - سروتونین حمل کنندهblood oxygenation level dependent - سطح اکسیژن خون وابسته استSAD - غمگینOrbital prefrontal cortex - قشر مغز پیشانیSubgenual anterior cingulate cortex - قشر مفصلی قدامی قدامیwhite matter hyperintensity - ماده تاریک ماده سفیدwhite matter - ماده سفیدBrodmann area - منطقه بردممنmonoamine oxidase A - مونوآمین اکسیداز AHPA - میلی بار یا هکتوپاسکالCopy number variant - نسخه شماره نسخه را کپی کنیدhypothalamic–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالPET - پتbinding potential - پتانسیل اتصال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Imaging techniques are a potentially powerful method of identifying phenotypes that are associated with, or are indicative of, a vulnerability to developing major depressive disorder (MDD). Here we identify seven promising MDD-associated traits identified by magnetic resonance imaging (MRI) or positron emission tomography (PET). We evaluate whether these traits are state-independent, heritable endophenotypes, or state-dependent phenotypes that may be useful markers of treatment efficacy. In MDD, increased activity of the amygdala in response to negative stimuli appears to be a mood-congruent phenomenon, and is likely moderated by the 5-HT transporter gene (SLC6A4) promoter polymorphism (5-HTTLPR). Hippocampal volume loss is characteristic of elderly or chronically-ill samples and may be impacted by the val66met brain-derived neurotrophic factor (BDNF) gene variant and the 5-HTTLPR SLC6A4 polymorphism. White matter pathology is salient in elderly MDD cohorts but is associated with cerebrovascular disease, and is unlikely to be a useful marker of a latent MDD diathesis. Increased blood flow or metabolism of the subgenual anterior cingulate cortex (sgACC), together with gray matter volume loss in this region, is a well-replicated finding in MDD. An attenuation of the usual pattern of fronto-limbic connectivity, particularly a decreased temporal correlation in amygdala-anterior cingulate cortex (ACC) activity, is another MDD-associated trait. Concerning neuroreceptor PET imaging, decreased 5-HT1A binding potential in the raphe, medial temporal lobe, and medial prefrontal cortex (mPFC) has been strongly associated with MDD, and may be impacted by a functional single nucleotide polymorphism in the promoter region of the 5-HT1A gene (HTR1A: â1019 C/G; rs6295). Potentially indicative of inter-study variation in MDD etiology or mood state, both increased and decreased binding potential of the 5-HT transporter has been reported. Challenges facing the field include the problem of phenotypic and etiological heterogeneity, technological limitations, the confounding effects of medication, and non-disease related inter-individual variation in brain morphology and function. Further advances are likely as epigenetic, copy-number variant, gene-gene interaction, and genome-wide association (GWA) approaches are brought to bear on imaging data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 164, Issue 1, 24 November 2009, Pages 300-330
Journal: Neuroscience - Volume 164, Issue 1, 24 November 2009, Pages 300-330
نویسندگان
J.B. Savitz, W.C. Drevets,