کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277670 | 1295771 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus
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کلمات کلیدی
tph2vlPAGanimal facility rearingdorsal raphe nucleus, interfascicular partCLicaudal linear nucleus of the rapheDRVDRDSSCPNDDRIAFRdorsal raphe nucleus, ventral partDRVLEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدstandard saline citrate - استاندارد سدیم سیتراتStress - استرس یا فشار روانیAnxiety - اضطرابDepression - افسردگیele - اوearly life experience - تجربه زندگی اولیهanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancematernal separation - جدایی مادرVentrolateral periaqueductal gray - خاکستری پرآلکتونی VentrolateralNeonatal handling - دست زدن به نوزادانpostnatal day - روز پس از زایمانSerotonin - سروتونینdorsal raphe nucleus - هسته رافهdorsal raphe nucleus, dorsal part - هسته ریف پشتی، قسمت پشتیtryptophan hydroxylase - هیدروکسیلاز تریپتوفانtryptophan hydroxylase 2 - هیدروکسیلاز تریپتوفان 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Anxiety disorders, depression and animal models of vulnerability to a depression-like syndrome have been associated with dysregulation of brain serotonergic systems. These effects could result from genetic influences, adverse early life experiences (ELE), or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to neuropsychiatric disorders. To evaluate the effects of ELE, adverse experiences during adulthood, and potential interactions between these factors on neuronal tryptophan hydroxylase 2 (tph2) mRNA expression, we investigated in rats the effects of maternal separation (MS)(separation from the dam for 180 min/day from postnatal day 2-14; MS180, a model of vulnerability to a depression-like syndrome), neonatal handling (separation from the dam for 15 min/day from postnatal day 2-14; MS15, a model of decreased stress sensitivity), or normal animal facility rearing (AFR) control conditions, with or without subsequent exposure to adult social defeat, on tph2 mRNA expression in the dorsal raphe nucleus (DR). Among rats exposed to social defeat, MS180 rats had increased tph2 mRNA expression in the DR, while MS15 rats had decreased tph2 mRNA expression compared to AFR rats. Social defeat increased tph2 mRNA expression, but only in MS180 rats and only in the “lateral wings” of the DR, a subdivision of the DR that is part of a sympathomotor command center. Overall, these data demonstrate that ELE and stressful experience during adulthood interact to determine tph2 mRNA expression. These changes in tph2 mRNA expression represent a potential mechanism through which adverse ELEs and stressful life experiences during adulthood may interact to increase vulnerability to stress-related psychiatric disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 163, Issue 4, 10 November 2009, Pages 991-1001
Journal: Neuroscience - Volume 163, Issue 4, 10 November 2009, Pages 991-1001
نویسندگان
K.L. Gardner, M.W. Hale, S. Oldfield, S.L. Lightman, P.M. Plotsky, C.A. Lowry,