کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6279167 | 1615069 | 2016 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A study of single nucleotide polymorphisms of GRIN2B in schizophrenia from Chinese Han population
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کلمات کلیدی
Grin2B(SNPs)(LD)(OR)(OCD)obsessive-compulsive disorder - اختلال وسواس فکری یا عملیSchizophrenia - اسکیزوفرنی یا شیزوفرنیLinkage disequilibrium - عدم تعادل پیوستگیconfidence intervals - فاصله اطمینانCase-control study - مطالعه مورد شاهدیodds ratio - نسبت شانس هاSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Schizophrenia is a severe and complex mental disorder with high heritability. There is evidence that mutations in the gene of Nmethyl-d-aspartate-type glutamate receptors (NMDAR) are associated with schizophrenia. GRIN2B encodes a subunit of NMDARs, and has been identified as a candidate gene for many psychiatric disorders, especially schizophrenia. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in GRIN2B were associated with schizophrenia. Four SNPs (rs890, rs1806191, rs219872, rs172677) were genotyped in 752 schizophrenic patients and 846 healthy controls of the Chinese Han population. Our results indicate differences in allele and genotype frequencies of rs890 between case and control. These results were assessed by adapting different genetic models (codominant, dominant, recessive, overdominant, log-additive models). After controlling for confounding factors including sex and age, rs890 remained associated with schizophrenia. In addition, rs890 and rs1806191 were found to form a haplotype associated with schizophrenia. In summary, our results indicate that the GRIN2B SNP rs890 might be associated with schizophrenia in the Chinese Han population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 630, 6 September 2016, Pages 132-135
Journal: Neuroscience Letters - Volume 630, 6 September 2016, Pages 132-135
نویسندگان
Zhenming Guo, Weibo Niu, Yan Bi, Rui Zhang, Decheng Ren, Jiaxin Hu, Xiaoye Huang, Xi Wu, Yanfei Cao, Fengping Yang, Lu Wang, Weidong Li, Xingwang Li, Yifeng Xu, Lin He, Tao Yu, Guang He,