کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6279744 1615080 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymorphisms in the receptor for advanced glycation end products gene are associated with susceptibility to drug-resistant epilepsy
ترجمه فارسی عنوان
پلیمورفیسم در گیرنده ژنهای پیشرفته گلیساسیون در گیرنده با حساسیت به صرع مقاوم به دارو همراه است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Increasing evidence has demonstrated that inflammation plays an important role in epilepsy (EP). As a cell-surface molecule of the immunoglobulin superfamily, the receptor for advanced glycation end products (RAGE) is involved in inflammation-related disease. Functional polymorphisms in the regulatory elements and/or ligand-binding regions of RAGE may alter the expression and function of RAGE, thus affecting EP susceptibility. Here, we have identified a novel association between genetic variants in the RAGE G82S locus and EP (p = 0.033) using a case-control study in a Chinese population. Further analyses showed that the 82S+ genotype and S allele were more common in patients with drug-resistant epilepsy (DRE) than in those with drug-responsive EP compared with controls. The loci -374 T/A and -429 T/C did not demonstrate any association with EP, but the haplotype T-A-A exhibited significantly different frequencies between DRE patients and controls (OR = 1.696, 95% CI: 1.188-2.420, P = 0.003). Our study provides preliminary evidence that the G82S polymorphism in RAGE is associated with increased DRE risk and that the GS genotype of the G82S locus is a risk factor for DRE in the Chinese population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 619, 21 April 2016, Pages 137-141
نویسندگان
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