Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; Oligomers; Oligomeropathy; Aβ; amyloid β-protein; AD; Alzheimer's disease; ADDL; Aβ-derived diffusible ligands; AFM; atomic force microscopy; APP; Aβ precursor protein; APP OSK mice; APP transgenic mice express
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Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β-protein; ANOVA; one-way analysis of variance; BSA; bovine serum albumin; CCO; cytochrome c oxidase; DTT; dithiothreitol; EDTA; ethylenediaminetetraacetic acid; ETC; electron transfer chain; ELISA; enzyme-linked i
Keywords: β-پروتئین آمیلوئید; RAGE; receptor for advanced glycation end product; AD; Alzheimer's disease; Aβ; amyloid β-protein; TLE; temporal lobe epilepsy; MHC; major histocompatibility; EEG; electroencephalography; MRI; magnetic resonance imaging; DRE; drug-resistant epilepsy;
Supratherapeutic concentrations of cilostazol inhibits β-amyloid oligomerization in vitro
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; AD; Alzheimer's disease; APP; amyloid precursor protein; APS; ammonium persulfate; αS; α-synuclein; CREB; cyclic adenosine monophosphate response element-binding protein; CSZ; cilostazol; DMTs; disease-modifying therapies; EM; e
Ac-LVFFARK-NH2 conjugation to β-cyclodextrin exhibits significantly enhanced performance on inhibiting amyloid β-protein fibrillogenesis and cytotoxicity
Keywords: β-پروتئین آمیلوئید; Amyloid β-protein; Peptide inhibitor; β-Cyclodextrin; Conjugation; Inhibition;
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; AD; Alzheimer's disease; HFIP; 1,1,1,3,3,3,-hexafluoroisopropyl alcohol; HMQC; heteronuclear multiple quantum coherence; HPLC; high performance liquid chromatography; LC-MS; liquid chromatography-mass spectrometry; LC/Q Tof-MS
RTHLVFFARK-NH2: A potent and selective modulator on Cu2+-mediated amyloid-β protein aggregation and cytotoxicity
Keywords: β-پروتئین آمیلوئید; Amyloid β-protein; Cu2+ chelator; Aggregation; Alzheimer's disease; Inhibitor; Peptide;
Ultrasensitive photoelectrochemical immunosensor for the detection of amyloid β-protein based on SnO2/SnS2/Ag2S nanocomposites
Keywords: β-پروتئین آمیلوئید; Label-free; Photoelectrochemical immunosensor; Alzheimer's disease; Amyloid β-protein; SnO2/SnS2/Ag2S nanocomposites;
CEPO-Fc (An EPO Derivative) Protects Hippocampus Against Aβ-induced Memory Deterioration: A Behavioral and Molecular Study in a Rat Model of Aβ Toxicity
Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β-protein; BBB; blood-brain barrier; CEPO-Fc; carbamylated erythropoietin-Fc; EPO; erythropoietin; ERK; extracellular signal-regulated kinase; JNK; Jun N-terminal kinase; MAPKs; Mitogen-activated protein kinases;
Charge effects of self-assembled chitosan-hyaluronic acid nanoparticles on inhibiting amyloid β-protein aggregation
Keywords: β-پروتئین آمیلوئید; Nanoparticle; Amyloid β-protein; Fibrillogenesis; Inhibition; Surface charge; Electrostatic interaction;
Brazilin inhibits the Zn2 +-mediated aggregation of amyloid β-protein and alleviates cytotoxicity
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; Brazilin; Inhibitor; Zn2 +;
High-glucose induces tau hyperphosphorylation through activation of TLR9-P38MAPK pathway
Keywords: β-پروتئین آمیلوئید; DM; diabetes mellitus; DE; diabetic encephalopathy; AD; Alzheimer's disease; NFTs; neurofibrillary tangles; SPs; senile plaques; Aβ; amyloid β-protein; TLR9; toll-like receptor 9; P38MAPK; P38mitogen-activated protein kinase; MAP; microtubule-associated
Synergistic effects of negatively charged hydrophobic nanoparticles and (â)-epigallocatechin-3-gallate on inhibiting amyloid β-protein aggregation
Keywords: β-پروتئین آمیلوئید; Polymeric nanoparticle; (â)-Epigallocatechin-3-gallate; Amyloid β-protein; Aggregation; Inhibition;
Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; Oligomers; Isolation; Protein structure; Protein function;
Modulation effect of acidulated human serum albumin on Cu2 +-mediated amyloid β-protein aggregation and cytotoxicity under a mildly acidic condition
Keywords: β-پروتئین آمیلوئید; Amyloid β-protein; Copper ion; Albumin; Negative charge; Mildly acidic condition; Aggregation; Aβ; amyloid β-proteins; AD; Alzheimer's disease; A-HSA; acidulated human serum albumin; ROS; reactive oxygen species; HSA; human serum albumin; ThT; thioflav
1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose binds to the N-terminal metal binding region to inhibit amyloid β-protein oligomer and fibril formation
Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β-protein; Aβ1-11; amyloid β-protein (1-11); Aβ11-22; amyloid β-protein (11-22); Aβ12-22; amyloid β-protein (12-22); Aβ25-35; amyloid β-protein (25-35); Aβ36-42; amyloid β-protein (36-42); Aβ1-
The Ï1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes
Keywords: β-پروتئین آمیلوئید; Ï1R; sigma (Ï)-1 receptor; Aβ; amyloid β-protein; AD; alzheimer disease; APP; amyloid precursor protein; CTX-HRP; Horseradish peroxidase-cholera toxin B subunit; DMEM; Dulbecco's modified Eagle's medium; DR; dopamine receptor; DRMs; detergent-resi
Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; Mitochondria; BACE1; γ-secretase; Subcellular fractionation;
TREMs in Alzheimer's disease: Genetic and clinical investigations
Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; TREM; Triggering receptor expressed on myeloid cells; TREML; TREM like transcript; NHD; Nasu-Hakola disease; NFTs; neurofibrillary tangles; p-tau; hyperphosphorylated tau; GWAS; genome-wide association studies; sTREM2; soluble f
Multifunctionality of self-assembled nanogels of curcumin-hyaluronic acid conjugates on inhibiting amyloid β-protein fibrillation and cytotoxicity
Keywords: β-پروتئین آمیلوئید; Curcumin-hyaluronic acid conjugate; Self-assembly; Hydrogel; Amyloid β-protein; Fibrillogenesis;
Negatively charged hydrophobic nanoparticles inhibit amyloid β-protein fibrillation: The presence of an optimal charge density
Keywords: β-پروتئین آمیلوئید; Polymeric nanoparticles; Amyloid β-protein; Surface charge; Hydrophobic binding; Electrostatic repulsion;
The N-terminal region of myelin basic protein reduces fibrillar amyloid-β deposition in Tg-5xFAD mice
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Myelin basic protein; Transgenic mice; Amyloid β-protein;
Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; AD; Alzheimer's disease; IP; immunoprecipitation; SEC; size exclusion chromatography; AβM; Aβ monomers; AβD; LDS-stable Aβ dimers; Chiro; chiro-inositol; Scyllo; scyllo-inositol; ICC; immunocytochemistry; IHC; immunohistochemi
Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; Immunotherapy; Oligomers; APP transgenic mice;
New mimetic peptides inhibitors of Îβ aggregation. Molecular guidance for rational drug design
Keywords: β-پروتئین آمیلوئید; Molecular modelling; Amyloid β-protein; Mimetic peptides; Aggregation modulating effect; Molecular dynamics simulations;
Featured ArticleThe aqueous phase of Alzheimer's disease brain contains assemblies built from â¼4 and â¼7 kDa Aβ species
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; Oligomers; SDS-Stable dimer;
Simultaneous measurement of a range of particle sizes during Aβ1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; Aβ1-42; Aβ spanning residues from Asp1 to Ala42; AD; Alzheimer's disease; CSF; cerebrospinal fluid; 5GDM; five Gaussian distribution model; FCS; fluorescence correlation spectroscopy; MEMFCS; maximum entropy method for FCS d
Differential effects of angiotensin II receptor blockers on Aβ generation
Keywords: β-پروتئین آمیلوئید; ARBs; angiotensin II receptor blockers; AD; Azheimer's disease; Aβ; amyloid β-protein; AT1a; angiotensin type 1a receptor; ACE; angiotensin converting enzyme; MEFs; mouse embryonic fibroblasts; hAPP695; human 695-amino acid amyloid precursor protein; AP
Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats
Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β; ANOVA; analysis of variance; BBB; blood-brain barrier; DPPIV; DPPIV dipeptidyl peptidase IV; fEPSPs; Field excitatory postsynaptic potentials; GLP-1; glucagon-like peptide-1; GLP-1R; GLP-1 receptor; GSK3β; gl
Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; AD; Alzheimer's disease; Act; actin; αS; α-synuclein; Cas; casein; EM; electron microscopy; Fibro; fibroin; fAβ; Aβ fibrils; fAct; Act fibrils; fCas; casein fibrils; fFibro; fibroin fibrils; fIAPP; IAPP fibrils; fSer; sericin
Active immunotherapy facilitates Aβ plaque removal following through microglial activation without obvious T cells infiltrating the CNS
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Microglial; Amyloid β-protein; T cell infiltration;
Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: Implications for a novel therapeutic strategy for Alzheimer's disease
Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; Aβ40; 40-mer amyloid β-protein; Aβ42; 42-mer amyloid β-protein; DIV; days in vitro; IgG; immunoglobulin G; iPSCs; induced pluripotent stem cells; MTT; 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NMR; nucle
Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; Episodic memory; Intracerebroventricular injection; Memory-associated synaptic reorganization; Non-fibrillar water-soluble Aβ; Passive avoidance; Synaptic plasticity;
The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells
Keywords: β-پروتئین آمیلوئید; Aβ; amyloidβ-peptide; AD; Alzheimer disease; APP; β-amyloid precursor protein; ESI; electrospray ionization; GAβ; ganglioside-bound Aβ; LC; liquid chromatography; MRM; multiple reaction monitoring; MS; mass spectrometry; MS/MS; tandem mass spectromet
Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; cor; corpus cerebelli; crcb; crista cerebelli; GD1a; Neu5Acα3-Galβ3GalNAcβ4(Neu5Acα3)Galβ4GlcCer; GD1b; Galβ3GalNAcβ4(Neu5Acα8Neu5Acα3)Galβ4GlcCer; ggl; ganglionic cell layer; GM1; Galβ3Gal-NAcβ4(Neu5Acα3)Galβ4GlcCer
Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; AFM; atomic force microscopy; AU; arbitrary unit; CD; circular dichroism; CSF; cerebrospinal fluid; Dai; daidzein; DTT; dithiothreitol; EM; electron microscopy; Equ; (±)-Equol; EM; emission; EX; excitation; fAβs; Aβ fibrils; Fo
Research ReportThe levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain
Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β-protein; TBS; Tris-buffered saline; TBS-TX; TBS containing 1% TX-100; FA; formic acid; IP; immunoprecipitation; CDR; clinical dementia rating; Alzheimer's disease; Amyloid β-protein; Water-soluble Aβ; SDS-stable
Inhibitory effect of Lavandula viridis on Fe2+-induced lipid peroxidation, antioxidant and anti-cholinesterase properties
Keywords: β-پروتئین آمیلوئید; ABTS+; 2,2â²-Azinobis-(3-ethylbenzothiazoline-6-sulphonic acid radical cation; ACh; Acetylcholine; AChE; Acetylcholinesterase; AD; Alzheimer's disease; ATCI; Acetylthiocholine iodide; Aβ; Amyloid β-protein; BChE; Butyrylcholinesterase; BTCI; Butyrylt
ER-stress-inducible Herp, facilitates the degradation of immature nicastrin
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; AD; Alzheimer's disease; APP; β-amyloid precursor protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; γ-secretase; Presenilin; Nicastrin; E3 ubiquitin ligase;
Research ReportSubcellular compartmentalization of proteolytic enzymes in brain regions and the effects of chronic β-amyloid treatment
Keywords: β-پروتئین آمیلوئید; Aβ; amyloid β-protein; APP; amyloid precursor protein; ROS; reactive oxygen species; DTT; dl-dithiothreitol; PMSF; phenylmethylsulfonyl fluoride; Ac-DEVD-pNa; N-acetyl-DEVD-p-nitroanilide; Ac-LEHD-pNa; N-acetyl-LEHD-p-nitroanilide; z-RR-AMC; benzyloxyca
Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid β-protein
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; GM1 ganglioside; Sphingomyelin; Endocytosis;
Inhibition and Modulation of γ-Secretase for Alzheimer's Disease
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; amyloid β-protein; amyloid precursor protein; Notch receptor; secretase; γ-secretase;
Tau overexpression in transgenic mice induces glycogen synthase kinase 3β and β-catenin phosphorylation
Keywords: β-پروتئین آمیلوئید; Alzheimer; transgenic; tau; GSK3; Wnt; aa; amino acid; Aβ; amyloid β-protein; AD; Alzheimer's disease; APP; amyloid precursor protein; EM; electron microscopy; GSK3β; glycogen synthase kinase 3β; NFT; neurofibrillary tangle; Non-tg; non-transgenic l
Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Aβ fibrillogenesis in Alzheimer's disease
Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β-protein; GM1; GM1 ganglioside; GAβ; GM1-bound Aβ; APP; amyloid precursor protein; apoE; apolipoprotein E; CTB; cholera toxin B subunit; HRP; horseradish peroxidase; NGF; nerve growth factor; Alzheimer's disea
GM1 ganglioside-mediated accumulation of amyloid β-protein on cell membranes
Keywords: β-پروتئین آمیلوئید; Amyloid β-protein; Ganglioside; Cholesterol; Alzheimer's disease; Lipid raft;
Age- and region-dependent alterations in Aβ-degrading enzymes: implications for Aβ-induced disorders
Keywords: β-پروتئین آمیلوئید; Amyloid β-protein; Insulin-degrading enzyme; Neprilysin; Aβ; AD; IDE; IBM;
Small non-fibrillar assemblies of amyloid β-protein bearing the Arctic mutation induce rapid neuritic degeneration
Keywords: β-پروتئین آمیلوئید; Alzheimer's disease; Amyloid β-protein; Arctic mutation; Protofibril; Oligomer; Neurofilaments; Primary neuron culture; Neurodegeneration; Aggregation;
Tau alteration and neuronal degeneration in tauopathies: mechanisms and models
Keywords: β-پروتئین آمیلوئید; AD; Alzheimer's disease; Aβ; amyloid β-protein; 3R; three-repeat tau; E; exon; 4R; four-repeat tau; FTDP-17; frontotemporal dementia and parkinsonism linked to chromosome 17; IR; inter-repeat; GSK-3β; glycogen synthase kinase-3β; MT; microtubule; MAP;