کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8947787 | 1645610 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ultrasensitive photoelectrochemical immunosensor for the detection of amyloid β-protein based on SnO2/SnS2/Ag2S nanocomposites
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
An ultrasensitive label-free photoelectrochemical (PEC) immunosensor with high visible-light activity was developed for quantitative detection of amyloid β-protein (Aβ) by cross-linking anti-Aβ antibody onto the Ag2S sensitized SnO2/SnS2 nanocomposites. Specifically, SnO2 with flower-like porous nanostructure was innovatively applied in PEC immunosensor as a basal material. It could form a heterostructure with SnS2, which brought about the sensitization of SnO2 and enhanced the separation of photogenerated electrons and holes. Moreover, Ag2S was in-situ growth on the surface of SnO2/SnS2, which further enhanced the photocurrent response significantly. Therefore, SnO2/SnS2/Ag2S could form stepwise band-edge structure, which benefited the light harvesting and provided a good foundation for sensor construction and detection. Under optimal conditions, the PEC immunosensor was used to detect the content of Aβ and exhibited a wide linear concentration range from 0.5â¯pgâ¯mLâ1 to 100â¯ngâ¯mLâ1, with low limit of detection (0.17â¯pgâ¯mLâ1) and limit of quantification (0.56â¯pgâ¯mLâ1). Additionally, the designed PEC immunosensor exhibited good reproducibility, specificity, and stability which may find potential applications in the biosensor, biomedicine, clinical diagnosis, photocatalysis and other related fields.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 120, 30 November 2018, Pages 1-7
Journal: Biosensors and Bioelectronics - Volume 120, 30 November 2018, Pages 1-7
نویسندگان
Yaoguang Wang, Dawei Fan, Guanhui Zhao, Jinhui Feng, Dong Wei, Nuo Zhang, Wei Cao, Bin Du, Qin Wei,