Chronic treatment with ascorbic acid enhances cortical spreading depression in developing well-nourished and malnourished rats

► We explore whether vitamin C alters cortical spreading depression in rats. ►The modulation of this effect by malnutrition was also studied. ► Results demonstrate a CSD-facilitation by vitamin C regardless of nutritional status. ► Vit C may act as prooxidant in view of the contrasting effect on CSD as compared with other antioxidants.