Trichinella spiralis: Infection changes serum paraoxonase-1 levels, lipid profile, and oxidative status in rats

► Paraoxonase-1 is an antiatherogenic enzyme by inhibiting lipid oxidation. ► The zoonotic nematode, Trichinella spiralis, infection decreases serum PON1 activity in rats. ► Also, T. spiralis infection induces an atherogenic lipid profile. ► These changes are associated with oxidative stress. ► Thus, nematode infection might have role in atherogenesis and insecticide metabolism.