کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6307914 | 1618836 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potential genotoxicity and risk assessment of a chlorinated flame retardant, Dechlorane Plus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
Dechlorane Plus (DP) is a chlorinated flame retardants that is globally ubiquitous. It is a potentially persistent organic pollutant (POPs) and an environmental toxin. However, the toxicity data is still limited and cannot provide a comprehensive environmental ecological risk assessment for DP. In this study, luminous bacteria, Vicia faba and Tetrahymena thermophila were chosen as testing organisms to investigate the acute toxicity and mutagenicity of DP. The concentration gradient of DP used in this study was chosen based on its environmental levels (experiments of luminous bacteria: 0.591, 2.95, 14.8, 73.8, 369 μg Lâ1; micronucleus tests: 2.4, 12, 60, 300, 1500 μg Lâ1; comet assay: 2.4, 12, 60, 300, 1500 μg Lâ1). For luminous bacteria, the relative luminosities were around 100% in treated groups, which suggested that there is no acute toxicity to luminous bacteria under the studied DP concentrations. The micronucleus test showed no significant difference between treatment and control groups, indicating no genotoxicity of DP. However the comet assay conducted with T. thermophila was relatively sensitive as there was a significant increase in DNA damage when the concentrations of DP increased from 300 to 1500 μg Lâ1, while the lower concentrations failed to show any treatment-related differences. Therefore, DP may pose a potential risk at concentration ⩾ 300 μg Lâ1. The results provide scientific information on the ecological risk assessment of DP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 135, September 2015, Pages 462-466
Journal: Chemosphere - Volume 135, September 2015, Pages 462-466
نویسندگان
Jing Dou, Yuan Jin, Yajie Li, Bing Wu, Mei Li,