کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6309683 | 1307453 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brief exposure to copper induces apoptosis and alters mediators of olfactory signal transduction in coho salmon
ترجمه فارسی عنوان
قرار گرفتن در معرض مواجهه با مس باعث آپوپتوز می شود و واسطه های انتقال سیگنال بویایی در ماهی قزل آلا
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کلمات کلیدی
ORNolfactory signal transductionACIIIOMPEOGcGMPcAMP - cAMPCyclic adenosine monophosphate - آدنوزین مونوفسفات CyclicOst - اورتApoptosis - خزان یاختهایCoho salmon - ماهی قزل آلاCopper - مسcyclic guanosine monophosphate - مونوفسفات گوانوزین چرخه ایolfactory receptor neuron - نورون گیرنده بویاییolfactory marker protein - پروتئین مارکر بویاییCNG channel - کانال CNGcyclic nucleotide-gated channel - کانال نوکلئوتیدی متوقف شده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Pacific salmon are particularly susceptible to copper (Cu)-induced olfactory injuries that can ultimately inhibit neurobehaviors critical to survival. However, the molecular mechanisms underlying Cu-mediated olfactory impairment remain poorly understood. In the present study, we conducted a short-term Cu exposure at levels relevant to urban runoff (5, 25 and 50Â ppb) , and investigated the roles of impaired olfactory signal transduction and induced apoptosis as underlying mechanisms of olfactory injury. Increased cell death in the olfactory epithelium was evident in coho receiving 4Â h exposures to 25 and 50Â ppb Cu. Expression of olfactory marker protein (omp), a marker of mature olfactory sensory neurons, also decreased at 50Â ppb Cu. Immunohistochemical analysis of coho olfactory epithelium demonstrated a loss of type 3 adenylate cyclase (ACIII) in the apical olfactory epithelium cilia at all levels of Cu exposure, suggesting an inhibitory effect of Cu in olfactory signaling. Accompanying the loss of ACIII in Cu-exposed coho were reduced intracellular cyclic guanosine monophosphate (cGMP) levels in the olfactory rosettes. Collectively, these results support a linkage among the initial steps of olfactory signaling in Cu-induced salmon olfactory injury, and suggesting that monitoring olfactory cGMP levels may aid in the assessment of salmon olfactory injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 93, Issue 10, November 2013, Pages 2639-2643
Journal: Chemosphere - Volume 93, Issue 10, November 2013, Pages 2639-2643
نویسندگان
Lu Wang, Herbert M. Espinoza, Evan P. Gallagher,