Effects of polychlorinated biphenyls on whole animal energy mobilization and hepatic cellular respiration in rainbow trout, Oncorhynchus mykiss

► We examine the energetic costs of exposure to PCBs in an in vivo and in vitro model. ► Rainbow trout are shown to mobilize glucose upon exposure to PCB 126. ► Rainbow trout hepatocytes have impaired mitochondrial respiration upon exposure to PCB 77. ► Impaired mitochondrial respiration may mask increases in whole animal energy demand.