Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells

► HHCB and AHTN can inhibit progesterone and cortisol production. ► HHCB and AHTN can down-regulate 3βHSD2 and CYP21. ► HHCB and AHTN can up-regulate CYP17, CYP11B1 and CYP11B2. ► AHTN can influence steroidogenesis by affecting MC2R expression.