کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6312373 | 1618967 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The relationship of cytotoxic and genotoxic damage with blood aluminum levels and oxidative stress induced by this metal in common carp (Cyprinus carpio) erythrocytes
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کلمات کلیدی
PCCLPXMNTMECCATCAAMPLGPXMNICyprinus carpioROS - ROSMicronucleus test - آزمون میکرونوکلئوسAluminum - آلومینیوم Canonical correlation analysis - تجزیه و تحلیل همبستگی کانونیterminal deoxynucleotidyl transferase dUTP nick-end labeling - ترمینال deoxynucleotidyl transferase dUTP نهایی پایان برچسبOxidative stress - تنش اکسیداتیوTUNEL - تونلmicronuclei - ریزهستک یا میکرونوکلئوس SOD - سدSuperoxide dismutase - سوکسوکس دیسموتازMolar extinction coefficient - ضریب انقراض مولیProtein carbonyl content - محتوای کربونیل پروتئینMicronucleus - میکروسکوپLipid peroxidation - پراکسیداسیون لیپیدPropidium iodide - پروتئین یدیدCatalase - کاتالازErythrocyte - گلبول قرمز یا اریتروسیتglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Aluminum is one of the most abundant elements in nature and is used in diverse industrial processes. As a result, it contaminates aquatic ecosystems, inducing damage on associated biota. In fish, it has been observed to induce hypoxia, hypercapnia, metabolic acidosis and respiratory arrest. Although there is little information on Al-induced cytotoxicity and DNA damage, this type of studies are essential in order to identify the mechanisms of action of this metal. The cytotoxic and genotoxic effects induced by Al on common carp (Cyprinus carpio) erythrocytes were determined in specimens exposed to 0.05, 120 and 239 mg Al Lâ1 in static exposure systems. Blood samples were taken at 12, 24, 48, 72 and 96 h, erythrocytes were separated, and the following were evaluated: frequency of micronuclei and frequency of terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells, blood Al levels, lipid peroxidation, protein carbonyl content, and activity of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase. The results show that tested aluminum concentrations produces oxidative stress (increase in lipid peroxidation degree and oxidized proteins content, as well as decrease in antioxidant enzymes activity) and induced higher frequencies of micronuclei and TUNEL-positive cells, so this metal can be considered as a cytotoxic and genotoxic agent for erythrocytes of common carp.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 96, 1 October 2013, Pages 191-197
Journal: Ecotoxicology and Environmental Safety - Volume 96, 1 October 2013, Pages 191-197
نویسندگان
Sandra GarcÃa-Medina, Judith Angélica Núñez-Betancourt, Alba Lucero GarcÃa-Medina, Marcela Galar-MartÃnez, Nadia Neri-Cruz, Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván,