کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6312865 | 1619036 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth
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کلمات کلیدی
MBzPmono-3-carboxypropyl phthalatemono-2-ethyl-5-hydroxyhexyl phthalatemono-2-ethyl-5-oxohexyl phthalatemono-2-ethyl-5-carboxypentyl phthalateMEOHPMEHHPMECPPmono-2-ethylhexyl phthalateMEHPLMEIQRBPAMiBPmono-n-butyl phthalateEFWMEPmCPPMBPEndocrine disruptors - اختلالهای غدد درون ریزstandard deviation - انحراف معیارMono-benzyl phthalate - بنزیل فتالاتBisphenol A - بیسفنول ای، بیسفنول ALOD یا Limit of detection - حد تشخیصhead circumference - دور سرAbdominal circumference - دور شکمFetal growth - رشد جنینbody mass index - شاخص توده بدنBMI - شاخص توده بدنیFemur length - طول فمورmono-ethyl phthalate - متیل فتالاتinterquartile range - محدوده بین محدبlimit of detection - محدودیت تشخیصGrowth restriction - محدودیت رشدmono-isobutyl phthalate - مونو ایزوبوتیل فتالاتbirthweight - وزن تولدEstimated fetal weight - وزن جنین تخمینیPlastics - پلاستیکPlasticizers - پلاستیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Growth of the fetus is highly sensitive to environmental perturbations, and disruption can lead to problems in pregnancy as well as later in life. This study investigates the relationship between maternal exposure to common plasticizers in pregnancy and fetal growth. Participants from a longitudinal birth cohort in Boston were recruited early in gestation and followed until delivery. Urine samples were collected at up to four time points and analyzed for concentrations of phthalate metabolites and bisphenol A (BPA). Ultrasound scans were performed at four time points during pregnancy for estimation of growth parameters, and birthweight was recorded at delivery. Growth measures were standardized to a larger population. For the present analysis we examined cross-sectional and repeated measures associations between exposure biomarkers and growth estimates in 482 non-anomalous singleton pregnancies. Cross-sectional associations between urinary phthalate metabolites or BPA and growth indices were imprecise. However, in repeated measures models, we observed significant inverse associations between di-2-ethylhexyl phthalate (DEHP) metabolites and estimated or actual fetal weight. An interquartile range increase in summed DEHP metabolites was associated with a 0.13 standard deviation decrease in estimated or actual fetal weight (95% confidence interval = â 0.23, â 0.03). Associations were consistent across different growth parameters (e.g., head circumference, femur length), and by fetal sex. No consistent associations were observed for other phthalate metabolites or BPA. Maternal exposure to DEHP during pregnancy was associated with decreased fetal growth, which could have repercussive effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 94, September 2016, Pages 531-537
Journal: Environment International - Volume 94, September 2016, Pages 531-537
نویسندگان
Kelly K. Ferguson, John D. Meeker, David E. Cantonwine, Yin-Hsiu Chen, Bhramar Mukherjee, Thomas F. McElrath,