Reconstructing pre-natal and early childhood exposure to multi-class organic chemicals using teeth: Towards a retrospective temporal exposome

- Humans are exposed to thousands of chemicals, many of which cross the placenta.
- Susceptibility to toxicants and their metabolites is heightened during early life.
- Biomarkers to assess past exposure to environmental chemical mixtures are lacking.
- We propose to retrospectively reconstruct the exposome at different life stages using teeth.
- Tooth-matrix biomarkers will advance the study of environmental determinants of health.