کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6330130 | 1619781 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant
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کلمات کلیدی
Caged fishSNRIsApISCITSSRIsSTP - PTSSER - برای بودنven - دوستSertraline - سرترالینFlu - سرفهCitalopram - سیتالوپرامFluoxetine - فلوکستینRainbow trout - قزل آلای رنگین کمانBrain - مغزselective serotonin reuptake inhibitors - مهار کننده های بازجذب سروتونین انتخابیserotonin–norepinephrine reuptake inhibitors - مهار کننده های بازجذب سروتونین-نوراپی نفرینActive pharmaceutical ingredients - مواد تشکیل دهنده دارویی فعالConcentration ratio - نسبت غلظتVenlafaxine - ونلافاکسینLiver - کبد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Tissue-specific bioconcentration of selected antidepressants was studied in rainbow trout (Oncorhynchus mykiss) exposed to undiluted effluent from a Swedish municipal sewage treatment plant for 13Â days. Citalopram, sertraline and venlafaxine were found in the brains and livers of most fish, but not in blood plasma or muscle. Venlafaxine was the only drug found in plasma (3/20 fish). Fluoxetine was not detected in any fish tissue, in accordance with a low concentration in the effluent and a comparably high limit of quantification in tissues. Concentrations of citalopram, sertraline and venlafaxine in fish brain were up to 1/12, 1/8 and 1/26, respectively, of the lowest concentrations found in the brains of mammals treated with therapeutic doses. Thus, given co-exposure to several antidepressants and an assumed similar potency in fish, the margin of safety for target-related effects in fish residing in effluent-dominated streams is relatively low. Furthermore, the non-detectable levels of these drugs in blood plasma suggest that analyses of concentrations in target tissues (brain) would be more informative in field studies and other studies with environmentally realistic exposure concentrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 488â489, 1 August 2014, Pages 46-50
Journal: Science of The Total Environment - Volumes 488â489, 1 August 2014, Pages 46-50
نویسندگان
Katerina Grabicova, Richard H. Lindberg, Marcus Ãstman, Roman Grabic, Tomas Randak, D.G. Joakim Larsson, Jerker Fick,