کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6481867 1557305 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of 13C NMR cross-polarization inversion recovery experiments for the analysis of solid dosage forms
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Application of 13C NMR cross-polarization inversion recovery experiments for the analysis of solid dosage forms
چکیده انگلیسی

Solid-state nuclear magnetic resonance (ssNMR) is a powerful and unique method for analyzing solid forms of the active pharmaceutical ingredients (APIs) directly in their original formulations. Unfortunately, despite their wide range of application, the ssNMR experiments often suffer from low sensitivity and peaks overlapping between API and excipients. To overcome these limitations, the crosspolarization inversion recovery method was successfully used. The differences in the spin-lattice relaxation time constants for hydrogen atoms T1(H) between API and excipients were employed in order to separate and discriminate their peaks in ssNMR spectra as well as to increase the intensity of API signals in low-dose formulations. The versatility of this method was demonstrated by different examples, including the excipients mixture and commercial solid dosage forms (e.g. granules and tablets).

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 513, Issues 1–2, 20 November 2016, Pages 538-542
نویسندگان
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