In situ DOX-calcium phosphate mineralized CPT-amphiphilic gelatin nanoparticle for intracellular controlled sequential release of multiple drugs

A co-delivery strategy has been developed to achieve the synergistic effect of hydrophobic drug (CPT) and hydrophilic drug (DOX) by utilizing the unique structure of amphiphilic gelatin/camptothecin@calcium phosphate-doxorubicin nanoparticles (AG/CPT@CaP-DOX).104