کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6487117 1372 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus
چکیده انگلیسی
The approach presented here significantly extended our ability to predict essential genes beyond orthologs and made it possible to predict an inventory of essential genes in Eukaryotic fungal species, amongst which a preferred subset of suitable drug targets may be selected. By selecting the best new targets, we believe that resultant drugs would exhibit an unparalleled clinical impact against a naive pathogen population. Additional benefits that a compendium of essential genes can provide are important information on cell function and evolutionary biology. Furthermore, mapping essential genes to pathways may also reveal critical check points in the pathogen's metabolism. Finally, this approach is highly reproducible and portable, and can be easily applied to predict essential genes in many more pathogenic microbes, especially those unculturable.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Biology and Chemistry - Volume 50, June 2014, Pages 29-40
نویسندگان
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