کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6490174 | 1416964 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metabolic modeling of the substrate competition among multiple VFAs for PHA production by mixed microbial cultures
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mixed microbial cultures (MMCs) are an effective method for polyhydroxyalkanoates (PHA) production. There are several models established to describe the metabolism of this process. Substrate competition was commonly found in the uptake of multiple volatile fatty acids (VFAs), thus this behavior should be considered in process modeling. In this study, a metabolic model is developed to describe for the first time the substrate competition among four commonly used VFAs (acetate, propionate, butyrate and valerate) in PHA production by MMCs. An inhibition parameter was introduced to describe the inhibition of butyrate and valerate on the uptake of acetate and propionate. The modeled results showed good agreement with experimental data within 95% confidence interval. This model enhanced the understanding of the metabolism of substrate uptake in PHA production, providing a successful approach to predict PHA composition and optimize the process efficiency when four competing VFAs are supplied.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biotechnology - Volume 280, 20 August 2018, Pages 62-69
Journal: Journal of Biotechnology - Volume 280, 20 August 2018, Pages 62-69
نویسندگان
Xiaofei Wang, Gilda Carvalho, Maria A.M. Reis, Adrian Oehmen,