Semi-solid-state fermentation: A promising alternative for neomycin production by the actinomycete Streptomyces fradiae

- We studied the production of neomycin by Streptomyces fradiae.
- Semi-solid-state fermentation led to higher neomycin production than SmF.
- The support used greatly influenced the production of neomycin by S. fradiae.
- Semi-solid-state fermentation holds great potential for neomycin production.