A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production

► The efficiency of cell factory rely on complex co-operation with dynamic variation of extracellular environment. ► Little reasonable knowledge with regard to when and how to improve surrounding environment in the bioprocess. ► We design a novel impeller configuration and CFD modeling, discovering a series of physiology response. ► This was also a case integrating fluid hydrodynamics and physiology which had been relatively few reported.