Convenient enzymatic resolution of cis-6-benzyltetrahydro-1H-pyrrolo[3,4-b]pyridine-5,7(6H,7aH)-dione using lipase to prepare the intermediate of moxifloxacin

- The optically pure (4aR,7aS)-1 was prepared using the enzymatic resolution.
- The target amine was obtained in high conversion and an excellent degree of enantiomeric purity.
- Chemo-enzymatic dynamic kinetic resolution for rac-cis-1 would be approached in the coming future.